|
KMID : 1033620210480010069
|
|
Clinical and Experimental Reproductive Medicine
2021 Volume.48 No. 1 p.69 ~ p.79
|
|
|
Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women
|
|
Sindiani Amer Mahmoud
Batiha Osamah
Al-zoubi Esra’a
Khadrawi Sara
Alsoukhni Ghadeer
Alkofahi Ayesha
Alahmad Nour Alhoda
Shaaban Sherin
Alshdaifat Eman
Abu-Halima Masood
|
|
|
Abstract
|
|
|
Objective: Poor ovarian response (POR) refers to a subnormal follicular response that leads to a decrease in the quality and quantity of the eggs retrieved after ovarian stimulation during assisted reproductive treatment (ART). The present study investigated the associations of multiple variants of the estrogen receptor 2 (ESR2) and follicle-stimulating hormone receptor (FSHR) genes with POR in infertile Jordanian women undergoing ART.
Methods: Four polymorphisms, namely ESR2 rs1256049, ESR2 rs4986938, FSHR rs6165, and FSHR rs6166, were investigated in 60 infertile Jordanian women undergoing ART (the case group) and 60 age-matched fertile women (the control group), with a mean age of 33.60±6.34 years. Single-nucleotide polymorphisms (SNPs) were detected by restriction fragment length polymorphism and then validated using Sanger sequencing.
Results: The p-value of the difference between the case and control groups regarding FSHR rs6166 was very close to 0.05 (p=0.054). However, no significant differences were observed between the two groups in terms of the other three SNPs, namely ESR2 rs1256049, ESR2 rs4986938, and FSHR rs6165 (p=0.561, p=0.433, and p=0.696, respectively).
Conclusion: The association between FSHR rs6166 and POR was not statistically meaningful in the present study, but the near-significant result of this experiment suggests that statistical significance might be found in a future study with a larger number of patients.
|
|
|
KEYWORD
|
|
|
Estrogen receptor, Follicle-stimulating hormone receptor, Ovarian stimulation, Single-nucleotide polymorphism
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|